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In a double-blind, randomized, controlled clinical trial, LAC was not inferior to amisulpride in relieving symptoms of dysthymic patients, showing an excellent profile of safety and tolerability [61]

They frequently present decreased caloric intake and increased metabolic requirements

Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M

This is an important task in light of the ever-growing prevalence of this disorder while no effective pharmacological treatment has been found so far