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In vitro and metagenomic screens also confirm that the cutC gene is concentrated in Clostridia and related anaerobes, while cntA is found chiefly in Gammaproteobacteria

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Interestingly, in selected cases with longstanding PIH that has not responded to topical treatment, very conservative fractional CO laser settings can help break up deeper pigment and encourage skin renewal

Allopurinol is the first-line urate-lowering agent