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Strikingly, deficiency in a single amino acid transporter, SLC7A5, is sufficient to phenocopy the effects of MYC deficiency, preventing most T cell growth and protein synthesis [3]
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Additional therapeutic strategies, such as the use of proton pump inhibitors (e.g., esomeprazole) to limit intestinal iron absorption, are also under clinical investigation [112]
used a repository of transcriptional responses to compounds, the Connectivity Map (cMap) [60], and MANTRA software ( to explore networks of compounds producing similar transcriptional responses
