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A few examples of the activities played by GSTs on antineoplastic agents and their contribution to drug resistance in cancer are the following: Cisplatin Platinum chemotherapeutic drugs are among the most extensively used anticancer agents 73
Additional studies suggested that reduced autophagy in AD brain and animal models is likely caused by the hyperactivation of the PI3K/Akt/mTOR axis
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This includes altered expression of mitochondria-related genes in prefrontal layer-III-PV neurons [111] and of the oxidative phosphorylation pathway resulting in OxS in interneurons derived from induced pluripotent stem cells [112]
