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These findings support a beneficial effect of Pycnogenol on cognitive functions in elderly people

Elevated serum cholesterol, liver damage, systemic inflammation, and hypoxic conditions can increase XO secretion via hepatic and other visceral pathways into the bloodstream and bind to the endothelial cell surface, initiating the overproduction of superoxide [77]

For example, medications affecting liver metabolism or blood-thinning drugs may require adjustments or closer monitoring during treatment