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For example, the hyperactivation of the PPP in CD4 + T cells from patients with SLE correlates with increased mTOR signaling, T cell survival, and pro-inflammatory cytokine production (157160)

In 2008, two independent postmortem studies reported that healthy embryonic mesencephalic neurons grafted into the striatum of PD patients developed -syn pathology or LB-like structures many years after brain surgery (Kordower et al., Multiple pre-clinical studies both in vitro and in vivo have demonstrated strong evidence supporting prion-like propagation and transmission of -syn (Spillantini et al., in vivo

Multicenter validation study of pathologic response and tumor thickness at the tumor-normal liver interface as independent predictors of disease-free survival after preoperative chemotherapy and surgery for colorectal liver metastases