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A critical role of glutathione in determining apoptosis sensitivity and resistance in leukemia cells

-L-glutamyl-L-cysteine can be a substrate for -glutamylcyclotransferase (GCT), however, due to higher affinity and activity of glutathione synthetase (GS), glutathione synthesis is favored in animal cells.[118] In the presence of GS and ATP, -L-glutamyl-L-cysteine is phosphorylated to form enzyme bound -glutamyl-cysteinyl-(P), which reacts with Gly to liberate free glutathione and Pi.[9] This pathway occurs virtually in all cell types (except epithelial cells), with liver being the major producer and exporter of glutathione

Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity