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c-h , IP1 levels, indicating Gq/11 activation, measured in mouse melanoma cell lines after 10 nM GRP stimulation, with or without treatment with the GRPR inhibitor RC-3095 ( c-h ) or pre-treatment with the ER inhibitor ICI-182,780 ( c-f )

[PUBMED Abstract] Jeha S, Goto H, Baruchel A, et al.: Patient-Level Meta-analysis of Clofarabine in Acute Lymphoblastic Leukemia

Imai and Guarente were key in discovering the sirtuin deacetylase activity in the 1990s