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Thymosin beta 4: an emerging therapeutic candidate for kidney diseases

Glucocorticoid regulation of corticotroph POMC transcription is also indirectly mediated via other mechanisms such as down-regulation of c-jun expression and direct protein-protein mediated inhibition of CRH-induced AP-1 binding (29), inhibition of CRH receptor transcription (30), inhibition of CRH/cAMP induced activation of Tpit/Pitx1, inhibition of CRH action via the Nur response element (12), and suppression of NeuroD1 expression which in turn inhibits the positive NeuroD1/E-box interaction in the POMC promoter (31)

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J Neurol Sci (1993) 118(2):1817.10.1016/0022-510X(93)90108-B 43 ScholteHRBuschHFBakkerHDBogaardJMLuyt-HouwenIEKuytLP