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Almost as alarming as the rise in abuse of the -ketoamphetamines is the paucity of data on their mechanisms of action and particularly their ability to damage the central nervous system, especially in light of the structural analogy of cathinone, methcathinone and methylone to amphetamine, methamphetamine (METH) and 3,4-methylenedioxymethamphetamine (MDMA), respectively (Kelly 2011)

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In addition to the previously discussed nutrient-sensing and autophagy pathways, the molecular landscape of inflammaging further encompasses several key regulatory signaling pathways: the cGAS-STING, Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathways, Wnt/-catenin signaling, and Notch signaling

Therefore, a first screening step in an alternative format to validate general functionality can massively reduce the workload and accelerate candidate selection