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Mechanistically, V-9302 sustained glutamine uptake by CD8 + T cells, by promoting the compensatory upregulation of the glutamine transporter ATB 0,+ / Slc6a14 , in CD8 + T cells, to support de novo glutathione synthesis and improve redox balance in T cells
10.3233/JND-230123 111 McDonaldD
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In the past, antibodies meant to activate TREM2 failed in clinical trialsthey turned out to drive internalization of the receptor, effectively switching it off
