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Proteolytic enzymes are frequently involved in bacterial colonization process, serving to degrade host proteins including immunoglobulin, nutrient acquisition and processing bacterial proteins necessary in pathogenesis (Maeda, 1996)

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In fact, at the end of the observation period, the improvement in FIQ-R scores indicated a shift in the severity level from severe (a score between 59 and 100) to moderate (a score between 39 and 58)

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they gradually develop over several weeks

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