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Their biological function is determined by their bioavailability, their anti-inflammatory, and antioxidant properties, and other activities such as vasodilatory, anticancer effects, and anti-ischemia [58]

In case of low bile acid absorption, FXR is not activated, FGF19 stays low and bile acid synthesis is stimulated

Other non-invasive strategies Besides the widely used strategies that have been discussed before, among which active strategies for BBB regulation and crossing are summarized in Table 1, there are more strategies that people used to achieve the intention of brain-targeted drug delivery (Fig

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