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7.5 Critical discussion of translational challenges The translation of ferroptosis-targeting agents for AD faces multiple interconnected challenges, with BBB penetration, off-target effects, long-term safety, and perturbations of iron metabolism and immune function being the most prominent

38 PapenbrockJ.GuretzkiS.HenneM

Bacterial invasion in the brain takes place through four processes, which include colonization, bacterial intrusion into the blood flow, survival in blood, and penetration into the subarachnoid space [28]
