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One of the limitation of the current study is that the sample size is too small

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The three ingredients with the strongest documented mechanisms for supporting melanin production in hair follicles are Bhringraj (which upregulates tyrosinase expression, the enzyme that synthesises melanin), Amla (which provides concentrated antioxidant protection to melanocytes and supports copper absorption for tyrosinase activity), and Mulethi (which contains glabridin, a compound that inhibits the enzyme responsible for melanin breakdown)