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High-precision epigenetic tools, such as clustered regularly interspaced short palindromic repeatsdead CRISPR-associated protein 9 (CRISPRdCas9) platforms, have been explored to target inhibitory marks on the FOXP3 promoter, indicating the conceptual feasibility of targeted epigenetic manipulation in RPL, although this approach remains preclinical (74)

doi: 10.1093/ajcn/87.2.424 143 NiculescuMDda CostaKAFischerLMZeiselSH

[DOI] [PubMed] [Google Scholar] 152.Heunks LM, Machiels HA, Dekhuijzen PN, Prakash YS, Sieck GC

94% of patients with fatty liver disease develop protective antibodies, however for other causes of chronic liver disease, the response is much lower