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Similarly, NAD + levels appear reduced in preclinical models of age-associated diseases, including ataxia-telangiectasia (A-T), mitochondrial myopathies, and Alzheimers disease (AD), and disease-matched clinical samples 114,242246

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This is often the case for older adults, individuals with certain digestive conditions, or those following specific diets
Neuropsychopharmacology 1996;15:45664