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Pharmacologic strategies of increasing NK-recognition of SCLC cells, including epigenetic regulators, could sensitize the tumor cells to therapeutic agents and to T-cell killing ( in vitro ( These studies confirm that there is significant benefit to adding PD1/PD-L1 inhibitors to first-line chemotherapy in extensive stage SCLC, while also underscoring the importance of investigating epigenetic regulators in SCLC