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In zebrafish, the colonization of the gut by microorganisms promotes epithelial absorption of fatty acids (Semova et al., 2012) and fish with intact microbiota have increased lipid accumulation in the intestinal epithelium, and increased expression of genes related to lipid metabolism compared to germ-free fish who lack microbiota (Sheng et al., 2018)

Beyond smoking, other environmental exposures also influence PRLM metabolism and the inflammatory balance

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54 Furthermore, GSH has also been found to be a key determinant of important biologic processes such as cell proliferation, apoptosis, immune function and fibrogenesis