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In conclusion, we confirm that artificially-methylated mtDNA promotes mitochondrial dysfunction (17) and disturbs the cellular lipid metabolism in the liver context

Since GSTO1 overexpression has been implicated in drug resistance, particularly to platinum compounds 7,18,19 , we tested the effects of GSTO1 inhibitors in combination with cisplatin in HCT116 cells

You have to go systematically until those issues are dealt with
