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Managing Side Effects: Temporary Discomfort and Risks of Epidural Steroid Injections Epidural steroid injections are considered a relatively safe and minimally invasive

Folic acid should be administered concomitantly if needed

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After one-third of the study participants have been enrolled and completed follow-up, the DSMBs will review the data and make recommendations concerning continuation, modification or termination of the study due to unexpectedly large beneficial effects or serious side effects and can suggest extension of the trial should the primary outcomes occur less often than anticipated