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The natural alkaloid piperlongumine significantly enhances tumor cell sensitivity to NK cellmediated killing by inducing ROS accumulation within tumor cells, disrupting protein homeostasis, and enhancing NK cell binding to tumor cells
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All samples from mice harboring at least one allele of Sst rtTA , Tet-O-Cre , and Lepr fl yielded the 400-bp band expected when recombination occurs ( Figure 2C ), likely reflecting DNA alterations in the delta cells
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