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Description
METH stimulates the release of excess glutamate from neurons while inhibiting its uptake by astrocytes, leading to the overactivation of NMDARs ( tThe excitotoxicity induced by METH also triggers neuroinflammation and amplifies its neurotoxic effects
Lancet 2001;358:17549.ArticlePubMed 33
This leaves practitioners in a difficult position: acknowledging a promising safety signal while recognizing the profound limitations of unpublished data

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