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When ACE2 cleaves a single amino acid from the C-terminus of angiotensin II the resulting peptide is referred to as angiotensin-(1-7)

Central to this concept linking neural and systemic functions is the concept of allostasis (adaptation) and allostatic load/overload (pathophysiology) [6] that emphasizes the role of endogenous mediators for adaptation in contributing to pathologies, including MDD, when activated persistently or dysregulated under circumstances of toxic stress and health-damaging behaviors (poor diet, excessive alcohol consumption, sleep deprivation and circadian disruption)

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