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Preconception and prenatal nutrition and neurodevelopmental disorders: a systematic review and meta-analysis
It is important to note that curcumin exhibits a biphasic dose-response relationship: lower doses activate protective pathwaysincluding increased total glutathione (GSx) and GST activitywhile higher doses deplete GSH, reduce related metabolites (e.g., taurine, homocysteine), and may induce pro-oxidant effects or cellular toxicity (Scharstuhl et al., 2009)
Kitakata H, Endo J, Matsushima H, Yamamoto S, Ikura H, Hirai A, Koh S, Ichihara G, Hiraide T, Moriyama H, Shirakawa K
