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Using structural analysis, v6pep (KEQWFGNRWHEGYR) was selected from the human CD44v6 domain that interacts with c-Met and inhibits tumor growth and metastasis in a pancreatic cancer model 112,113
The second peak, mediated at least in part by NOX1, NOX3 and mitochondrial enzymes, results in prolonged signaling through PI3K, NF-B, and AKT
