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Why Medical Experts Continue to Urge Caution Despite growing interest, several important limitations remain

Therefore, it would be challenging to deliver an effective therapeutic concentration through the nostrils as the intranasal dosing volume may be a rate-limiting factor compared to traditional routes
A cross-sectional study in 2023 reported that 17.7% of the patients with vitiligo had one or more autoimmune comorbidities (Rios-Duarte et al., 2023)

Similarly, metabolites potentially derived from gut microbiota were reported to be associated with renal and cerebrovascular endothelial, podocyte, and proximal tubule damage in early diabetic kidney disease in diabetes Mellitus patients (Balint et al., 2023b)
