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Enzyme induction doesnt occur immediately, but rather seems to emerge over several days

Regulation of molecular modification and epigenetic reprogramming The frequent occurrence of molecular modification in cancer involves alterations in DNA or RNA promoter regions, histone acetylation, methylation, or variations in repetitive element expression

Decline of lactate in tumor tissue after ketogenic diet: in vivo microdialysis study in patients with head and neck cancer

Since disulfiram was previously shown to have a sub-micromolar IC 50 [37] (see also dose response data for disulfiram in Additional file 1: Figure S7), the goal was to identify superadditive drug combinations that involve disulfiram