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Balasubramanyam, A Association of TCF7L2 variation with single islet autoantibody expression in children with type 1 diabetes BMJ Open Diabetes Res Care 2 1: e000008

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In some patients with ITP, no autoantibodies to platelet membrane glycoproteins have been detected, and abnormalities in their cellular immune mechanisms are also an important part of the pathogenesis of ITP, including impaired megakaryopoiesis, Th1/Th2 imbalance, alteration of the ratio of helper T-cells, macrophage and dendritic cell messaging, CD8+ T-cells inducing platelet destruction either directly or indirectly, and a dysfunction of the balance of Th17/Tregs, etc

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