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These coordinated molecular perturbations manifest physiologically as systemic glucose disposal deficits, compensatory hyperinsulinemia, and progressive advancement toward metabolic syndrome

Mature islet cells lack the expression of YAP, while overexpression of YAP in islets is associated with proliferative and antiapoptotic effects

Glutatyon, yapsndaki tiyol grubu nedeniyle hava, k ve s ile temas ettiinde okside olabilir ve bu da etkinliini drr

46, 47 On the other hand, it results in the inactivation of (at least a fraction of) chemically reactive CDDP, hence functioning as a cytoprotective buffer
