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Additional alkyne-functionalized analogs of selected fragments ( 24 - 26 ) were synthe-sized and directly assessed for their ability to label proteins (Figure S4)

Sirts have also been linked to longevity in model organisms and protective effects in cardiac and neuronal models.13 A recently identified NAD+ hydrolase, Sterile Alpha and Toll/Interleukin-1 Receptor motif-containing 1 (SARM1), is implicated in the aging and regeneration of neurons (21,22)

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References Paglia DE, Valentine WN: Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase
