Glutathione oxidized (GSSG)
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The results demonstrated that NaF activated the downstream PI3KAKT, MAPK, and FOXO pathways by regulating the BDNFTrkB pathway through SIRT1, inhibited cell proliferation, blocked the cell cycle, and promoted apoptosis
PMCID: PMC4328900
[DOI] [PMC free article] [PubMed] [Google Scholar] 13.Xu X., Kim J.J., Li Y., Xie J., Shao C., Wei J.J
The genes encoding for these enzymes are positively regulated by the oncogene AKT which acts upstream the transcription factor Nrf2
