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8 , 14835 doi: 10.1038/ncomms14835 (2017)

Risk factors include the speed and magnitude of weight loss, pre-existing nutritional deficiencies, age, sex (women are more commonly affected), and individual genetic susceptibility

Refsum, H

This cytotoxic effect is shared with lamotrigine and appears to be contrary to the cytoprotective effects of certain microbial metabolites
