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When ferroptosis occurs, lipid peroxidation caused by ferroptosis will destroy the cell membrane of IEC, disintegrate IEC, making it unable to secrete mucus to protect the intestine, and disrupt the intestinal mucosal barrier ( 4.2 Iron deposition disrupts the immune system and aggravates UC In 2004, Gasche proposed that a certain amount of iron is essential for lymphocyte development, but iron deposition in immune cells hinders basic immune functions and the hosts resistance to invading pathogens ( The imbalance in iron homeostasis affects the cytokine activity of macrophages and cell-mediated immune response mechanisms

doi: 10.3390/antiox12020310 137 XuCSunSJohnsonTQiRZhangSZhangJet al

(12) Zhu Y et al., Effect of antioxidant N-acetylcysteine on diabetic retinopathy and expression of VEGF and ICAM-1 from retinal blood vessels of diabetic rats, Mol Biol Rep, 2012, 39(4):3727-35

[DOI] [PMC free article] [PubMed] [Google Scholar] 405.Raymond-Lezman J.R., Riskin S.I