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Tri-Luma cream containing hydroquinone 4%, tretinoin 0.05%, and fluocinolone acetonide 0.1% has been authorized by the FDA for melasma management and should be applied once daily on the affected facial areas for at least 8 weeks (Spierings, 2020)

Infection control is another key activity of the immune system and is closely associated with NF- B

The metabolic profiles of immune cells significantly vary based on their differentiation and functional states
