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Interleukin-12/23 Inhibitors Ustekinumab (UST) is the only anti-interleukin (IL)-12/IL-23 approved for UC at this time, and acts by binding to the p40 subunit of IL-12 and IL-23, preventing the interaction of these cytokines with the IL-12 receptor 1 subunit of the IL-12 and IL-23 receptor complexes, thus affecting lymphocytes' function and downregulating proinflammatory cytokines

All patients were fully supplemented with folic acid and vitamin B12

Recombinant adjuvanted zoster vaccine and reduced risk of coronavirus disease 2019 diagnosis and hospitalization in older adults

Progesterone has the opposite effect and appears to potentiate GABA receptor activity and reduce neuronal discharge rates