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They are responsible for carrying slow, dull, and diffuse pain sensations, as well as transmitting information related to temperature, especially cold sensations
The results demonstrated its effect on the treatment of estrogen-dependent mammary tumor cells (MCF-7 and MC4L2) and proliferation of triple-negative breast cancer (4T1) [162]
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The PI3K-driven AKT activation leads to a direct regulation of glycolytic enzymes and activation of mTOR
