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While notable scientific and translational challenges remain, concerted efforts to elucidate context-dependent mechanisms, develop precision biomarkers and tools, and rigorously evaluate targeted combinations in the clinic are poised to yield transformative advances

--- ## Storage and Handling Summary | Condition | Pre-Reconstitution | Post-Reconstitution | |-----------|-------------------|---------------------| | Temperature | Room temp or refrigerator | 28C (refrigerator only) | | Light | Protect from direct light | Protect from light | | Freeze

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Treatment with hesperidin significantly reduced neutrophil infiltration, edema, colon shortening, and macro and microscopic damages induced by intracolonic administration of acetic acid in mice [166]