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They observed significantly high arteriolar dilation and increased capillary perfusion in the treatment group with 100mg/kg NAC, which led to reduced ischemia and apoptotic cell death in all areas of the flap

Nelson DL, Cox MM

This requirement for CoA could, as hypothesized, reflect a role for SNO-CoA in delivering the modifications, or it is possible that CoA binding to the E2 subunit induces a conformational change allowing the lipoic arm to be more effectively modified