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Simply, GH and IGF1 regulate the process by promoting cell proliferation through janus kinase 2/signal transducer and activator of transcription 5 (JAK2/STAT5) signaling pathway or phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) and mitogen-activated protein kinase/extracellular regulated MAP kinase 1/2 (MAPK/ERK1/2) pathways, inducing homologous recombination (HR) or non-homologous end joining (NHEJ) to repair DNA damage and decreasing pro-apoptotic molecules (Bax, caspase3) (Valenciano et al., 2012

Its often compared with TB-500 or GH fragments to study recovery pathways

Its relatively small size and well-characterised binding chemistry make it a practical tool for investigating copper-mediated biological processes in both in vitro and in vivo models

Consequently, vitamin B 12 deficiency rarely occurs before the infant is about 4 months old if the mother has adequate vitamin B 12 status during pregnancy