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2019 doi: 10.1155/2019/6320163

Considering that (1) MDD is a chronic stress condition with reduced HRV [29], and reduced autonomic responses to acute stress [5] and (2) taVNS can selectively activate vagal afferents and modulate the central autonomic network, we hypothesized that taVNS would increase acute stress reactivity, restore blunted HRV, and reduce inflammatory response to acute stress in participants with MDD and healthy controls

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