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The transport mechanism of CLCs has been well established by structural studies which revealed a homodimeric architecture with each protomer bearing a separate ion transport pathway and three consecutive substrate-binding sites referred to as the external site (S ext ), central site (S cen ) and internal site (S int ) 15,16,17,18,19,20,21,22,23,24,25

2016 Aug 1;176(8):1134-45

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Research reported that the higher the concentration of ascorbate in blood is, the greater the time it is required to initiate lipid peroxidation with no pro-oxidant effects, even in ascorbate serum concentrations of 5 mM achievable only parenterally (Frei et al., 1989)