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A meta-analysis of five randomized trials found that cyclobenzaprine produced modest pain reduction without affecting fatigue or sleep

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The estimates of DILI incidence fluctuate significantly, from 1 in 10,000 to 1 in 1,000,000 cases, influenced by variable factors such as diagnostic criteria, detection capabilities, population demographics, drug types, cultural factors, and reporting practices
Bibcode:1995PNAS...92.4158T
