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Equilibration: Allow the sealed vial to reach room temperature prior to laboratory handling

Subsequent chemical reactions, such as rearrangements and cross-linking processes, result in the loss of normal function for these biological macromolecules
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In a 12-week multicenter RCT involving 90 infants with atopic dermatitis, 7-month synbiotic supplementation reduced the incidence of recurrent wheezing and respiratory symptoms, along with decreased asthma medication use, although no significant differences in total IgE levels were observed (Meirlaen et al., 2021)
