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The issue is balance

Am J Hum Genet 2007;80:407-15.ArticlePubMedPMC 61

The allosteric switch operated by the bias expresses the difference between the observable and invisible pre-existing states
10.1038/s41598-024-61011-8 46 GuY.XuX.WangZ.XuY.LiuX.CaoL.et al (2018)