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doi: 10.1186/s13046-021-02134-y
Studies indicate that competitive consumption of methionine by tumor cells can lead to methionine metabolic deficiency in CD4 + T cells, which in turn suppresses AMPK expression by reducing histone H3K79me2 methylation levels (53, 54)
That is, chronic hypoxia steadily promoted the expression of Acer2 (Fig
