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Peer review Peer review information Nature Communications thanks Gregers Jungersen, and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

This article summarizes current progress in understanding the machinery of Exos biogenesis

61% of patients have reported being bedbound on their worst days (41) and at least one-quarter of ME/CFS patients have recounted being housebound or bedbound at some point in their lives (2)