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The LAT1 transporter is highly expressed in brain tissue and placenta along with cancer cells, where it supports amino acid and nutrient supply under nutrient-limited conditions

All Western blotting experiments were performed in triplicate using biologically independent samples, and consistent results were obtained in the replication experiments

Xiang-Yu Liu, Guoxiao Wang, Yingying Yu, Haopeng Xiao, Kentaro Oh-hashi, Xu Shi, Shuning Zheng, Robert Gerszten, C

Asparaginases from bacteria have significant clinical utility as they are used in the treatment of several forms of hematopoietic malignancies that express low levels of the ASNS gene and, therefore, rely on extracellular asparagine for their rapid growth