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Significantly, a compound denoted as melatonin-trientine, covalently synthesized with melatonin and the metal ion chelator trientine, demonstrated the capacity to elevate the expression of IDE in a murine AD model, and decreased A deposition and neuronal degeneration in the brains of the APP/Presenilin 1 mice [65]
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[DOI] [PMC free article] [PubMed] [Google Scholar] 124.Estrela JM, Gil F, Vila JM, Vina J
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