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The importance of glutathione for the management of reactive oxygen species and the link between low glutathione and a variety of conditions have led to the product being studied for an extremely wide range of indications including Parkinsons disease, cystic fibrosis, autism spectrum disorder (ASD), and hyperpigmentation among others

The role of GM-derived TMAO in OP necessitates further exploration

There is currently no conclusive clinical research evidence to support this

However, their modest efficacy in slowing GA lesion growth without demonstrating clear functional benefit, the burden of monthly or bi-monthly intravitreal injections, and potential safety concerns, including an increased risk of conversion to neovascular AMD, have limited their clinical use and precluded regulatory approval in Europe